General
Preferred name
FOSFRUCTOSE
Synonyms
D-Fructose-1,6-bisphosphate , sodium salt, hydrate (1:3:8) ()
Diphosphofructose ()
Esafosfan ()
FDP ()
D-fructose-1,6-bis(dihydrogen phosphate) ()
D-Fructose-1,6-Diphosphate ()
Fosfructose, sodium salt, hydrate (1:3:8) ()
D-Fructose-1,6-bisphosphate (sodium salt hydrate) ()
P&D ID
PD077476
CAS
488-69-7
81028-91-3
Tags
available
covalent binder
drug candidate
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
D-Fructose-1,6-bisphosphate sodium salt hydrate is the intermediate in carbohydrate metabolism, including glycolysis and gluconeogenesis. During glycolysis, it is produced by phosphorylation of fructose-6-phosphate by phosphofructokinase. The reverse reaction mediated by fructose-1, 6-diphosphatase-1 is one of the rate-limiting steps of gluconeogenesis. The same reaction occurs in the chloroplasts of plants, D-Fructose-1,6-bisphosphate sodium salt hydrate as part of the reducing pentose phosphate cycle. Since cancer cells use glycolysis as a primary source of metabolic energy production, this pathway has become a major target for cancer chemotherapy.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
7
Cayman Chemical Bioactives
CovBinderInPDB
CBR002225
CBR002226
CBR002227
CBR002228
CBR002229
CBR002230
CBR002231
CBR002232
CBR002233
CBR002234
CBR005301
CBR005302
CBR005303
CBR005304
CBR005305
CBR005306
CBR005307
CBR005308
CBR005309
CBR005310
CBR005311
CBR005312
CBR005313
CBR005314
CBR005315
CBR005316
CBR005317
CBR005318
CBR005319
CBR005320
CBR007480
CBR007484
CBR007486
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TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
340.0
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
7
Rotatable Bonds
9
Ring Count
0
Aromatic Ring Count
0
cLogP
-3.14
TPSA
211.28
Fraction CSP3
0.83
Chiral centers
3.0
Largest ring
0.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
fructose diphosphate stimulant
Pathway
Metabolic Enzyme/Protease
Target
Endogenous Metabolite
Source data
