General
Preferred name
Firsocostat
Synonyms
ND-630 ()
NDI-010976 ()
GS-0976 ()
NDI-010976, ND-630 ()
Firsocostat (GS-0976) ()
GS-ACC ()
P&D ID
PD076962
CAS
1434635-54-7
Tags
available
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Non-alcoholic steatohepatitis
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively.
PRICE
387
DESCRIPTION
Firsocostat (GS-0976) is a liver-directed acetyl-CoA carboxylase (ACC) inhibitor . It was initially identified by Nimbus Therapeutics , and is being developed by Gilead as an antilipemic agent for potential to treat non-alcoholic steatohepatitis (NASH) . Firsocostat is an allosteric inhibitor that binds to the ACC biotin carboxylase dimerization site, rather than to the previously targeted carboxyltransferase domain. The firsocostat-ACC interaction mimics the physiological inhibition of ACC by AMPK.
(GtoPdb)
DESCRIPTION
Firsocostat (GS-0976) is an inhibitor of acetyl-CoA carboxylase (ACC) dimerization that inhibits human ACC1 and ACC2 activity (IC50s of 2.1 and 6.1 nM, respectively)
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
14
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
ChEMBL Drugs
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
EU-OPENSCREEN Bioactive Compound Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
569.18
Hydrogen Bond Acceptors
11
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
5
Aromatic Ring Count
4
cLogP
3.95
TPSA
135.02
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
6.0
QED
0.32
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
ACC
acetyl-CoA carboxylase
MOA
acetyl-CoA carboxylase inhibitor
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data
