General
Preferred name
PFE-PKIS 34
Synonyms
CP-690550A ()
PFE-PKIS_34 ()
P&D ID
PD076865
CAS
1243290-37-0
Tags
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
This active molecular is a novel Janus Kinase 3 (JAK3) inhibitor. CP-690550A is an immunosuppressant for the treatment of rheumatoid arthritis, psoriasis, transplant rejection and other immune-mediated disorders.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
BOC Sciences Bioactive Compounds
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
Kinase Chemogenomic Set (KCGS 08/2017, in progress)
Kinase Chemogenomic Set (KCGS)
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
7
Molecular Weight
303.17
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
0.62
TPSA
85.35
Fraction CSP3
0.53
Chiral centers
2.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
JAK3, JAK2
Solubility
Soluble in DMSO
Source data
