General
Preferred name
elenbecestat
Synonyms
E2609 ()
E-2609 ()
N-{3-[(4aS,5R,7aS)-2-amino-5-methyl-4H,4aH,5H,7H,7aH-furo[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl}-5-(difluoromethyl)pyrazine-2-carboxamide ()
P&D ID
PD076489
CAS
1388651-30-6
Tags
available
drug candidate
Drug indication
Alzheimer disease
Drug Status
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Elenbecestat (E2609) is a potent, orally bioavailable and CNS-penetrant BACE-1 inhibitor. Elenbecestat has the potential for Alzheimer's disease (AD) research[1][2].
PRICE 235
DESCRIPTION BACE1 inhibitor for Alzheimer's disease jointly developed by Eisai and Biogen Inc. Phase 3 clinical study and FDA granted Fast Track designation. As of Feb 2018 no peer reviewed journal publications but structure identified in the patent . (GtoPdb)
DESCRIPTION Elenbecestat is a novel, potent and orally bioavailable BACE1 inhibitor for the treatment of Alzheimer's disease (AD), which demonstrates prolonged reductions in plasma beta-amyloid levels after single dosing. (BOC Sciences Bioactive Compounds)
DESCRIPTION Elenbecestat (E2609) is an effective oral bioutilization and CNS penetrating ACE-1 inhibitor for the treatment of Alzheimer's disease. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
9
BOC Sciences Bioactive Compounds
elenbecestat-cas-1388651-30-6-334146
ChEMBL Drugs
CHEMBL4204869
DrugBank
DB15391
DrugMAP
DMTNUJ8
Guide to Pharmacology
9818
MedChem Express Bioactive Compound Library
HY-109055
ReFrame library
Selleckchem Bioactive Compound Library
elenbecestat
TargetMol Bioactive Compound Library
T11175
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
437.11
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
3.1
TPSA
102.49
Fraction CSP3
0.37
Chiral centers
3.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
BACE1
Beta-secretase
BACE
Pathway
Neuronal Signaling
Neuroscience
Solubility
DMSO: 87 mg/mL
Ethanol: 11 mg/mL
Source data