General
Preferred name
Epiblastin A
Synonyms
P&D ID
PD076464
CAS
16470-02-3
Tags
available
obsolete probe
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Epiblastin A is an ATP competitive casein kinase 1 (CK1) inhibitor with IC50s of 8.9, 0.5, and 4.7 ¦ÌM for CK1¦Á, CK1¦Ä, and CK1 ?, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1[1].
PRICE 31
DESCRIPTION Epiblastin A is an inhibitor of Casein Kinase 1 (CK1). Epiblastin A engages CK1 isoenzymes in cell lysate and induces efficient conversion of epiblast stem cells (EpiSCs) into embryonic stem cells (cESCs). (TargetMol Bioactive Compound Library)
DESCRIPTION Potent HMG-CoA reductase inhibitor (Tocris Bioactive Compound Library)
Compound Sets
5
Cayman Chemical Bioactives
22758
MedChem Express Bioactive Compound Library
HY-114858
Obsolete Compounds
epiblastin
TargetMol Bioactive Compound Library
T8987
Tocris Bioactive Compound Library
6340
External IDs
7
Properties
(calculated by RDKit )
Molecular Weight
287.07
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
3
Aromatic Ring Count
3
cLogP
1.49
TPSA
129.62
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.62
Structural alerts
1
historic compounds (Chemical Probes.org)
Obsolete
Custom attributes
(extracted from source data)
Target
Casein kinase
CK1
Primary Target
Casein Kinase 1
MOA
Inhibitor
Pathway
Cell Cycle/DNA Damage
Stem Cell/Wnt
Metabolism
Stem Cells
Source data