General
Preferred name
Tofogliflozin (hydrate)
Synonyms
TOFOGLIFLOZIN HYDRATE ()
CSG-452 hydrate ()
Tofogliflozin(CSG 452) ()
TOFOGLIFLOZIN ()
Tofogliflozina ()
Tofogliflozin hydrate ()
Tofogliflozine ()
Tofogliflozin monohydrate ()
CSG452 ()
Tofogliflozin ()
P&D ID
PD076456
CAS
1201913-82-7
Tags
available
drug
Drug Status
approved
Max Phase
4.0
Drug indication
Non-alcoholic steatohepatitis
First approval
2014
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific sodium/glucose cotransporter 2 (SGLT2) inhibitor with an IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2[1]. Tofogliflozin partially inhibits high glucose-induced reactive oxyen species (ROS) generation in tubular cells[2].
PRICE 122
DESCRIPTION Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2, with an IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2, respectively. (TargetMol Bioactive Compound Library)
Compound Sets
7
Cayman Chemical Bioactives
23509
ChEMBL Approved Drugs
CHEMBL2105711
ChEMBL Drugs
CHEMBL2105711
EU-OPENSCREEN Bioactive Compound Library
EOS100802
MedChem Express Bioactive Compound Library
HY-13413
Selleckchem Bioactive Compound Library
tofogliflozin-csg-452
TargetMol Bioactive Compound Library
T5016
External IDs
10
Properties
(calculated by RDKit )
Molecular Weight
404.18
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
4
Aromatic Ring Count
2
cLogP
0.17
TPSA
130.88
Fraction CSP3
0.45
Chiral centers
5.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Reactive Oxygen Species
ROS
SGLT
SGLT2
Reactive Oxygen Species (ROS)
Pathway
NF-¦ÊB
GPCR/G protein
Immunology/Inflammation
Metabolism
NF-κB
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
Source data