General
Preferred name
OXINDOLE
Synonyms
Indolin-2-one ()
2-Indolinone ()
2-indolone, 2-Oxindole, Indolin-2-one ()
P&D ID
PD076198
CAS
59-48-3
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.
PRICE 29
DESCRIPTION Oxindole (Indolin-2-one) is an aromatic heterocyclic building block, and its 2-indolinone derivatives are lead compounds in kinase inhibitor research. The oxindole structure is utilized in receptor tyrosine kinase (RTK) inhibitors, such as SU4984 and intedanib, making the RTK family a significant therapeutic target for anti-cancer drug development. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
4
Cayman Chemical Bioactives
23851
MedChem Express Bioactive Compound Library
HY-Y0061
Selleckchem Bioactive Compound Library
oxindole
TargetMol Bioactive Compound Library
Fr16741
External IDs
30
Properties
(calculated by RDKit )
Molecular Weight
133.05
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
2
Aromatic Ring Count
1
cLogP
1.18
TPSA
29.1
Fraction CSP3
0.12
Chiral centers
0.0
Largest ring
6.0
QED
0.57
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
HIV
Endogenous Metabolite
Bacterial,HIV
Pathway
Microbiology/virology
Proteases/Proteasome
Anti-infection
Metabolic Enzyme/Protease
Source data