General
Preferred name
VALOPICITABINE
Synonyms
VALOPICITABINE DIHYDROCHLORIDE ()
Valopicitabine (dihydrochloride) ()
NM283 (dihydrochloride) ()
NM-283 ()
Valopicitabina ()
NM-283 DIHYDROCHLORIDE ()
NM283 ()
P&D ID
PD076103
CAS
640281-90-9
640725-71-9
Tags
available
prodrug
drug candidate
Drug indication
Virus infection
chronic hepatitis C virus infection
Drug Status
experimental
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Valopicitabine (NM283) dihydrochloride is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination[1][2].
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
5
ChEMBL Drugs
DrugBank
DrugMAP
MedChem Express Bioactive Compound Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
30
Molecular Weight
356.17
Hydrogen Bond Acceptors
10
Hydrogen Bond Donors
5
Rotatable Bonds
5
Ring Count
2
Aromatic Ring Count
1
cLogP
-1.4
TPSA
163.91
Fraction CSP3
0.67
Chiral centers
5.0
Largest ring
6.0
QED
0.4
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Pathway
Anti-infection
Cell Cycle/DNA Damage
Metabolic Enzyme/Protease
Target
HCV
HCV Protease
Nucleoside antimetabolite/analog
Source data
