General
Preferred name
DAVA
Synonyms
5-AMINOPENTANOIC ACID HYDROCHLORIDE ()
5-Aminovaleric acid hydrochloride ()
Delta-Amino Valeric Acid ()
5-Aminovaleric acid ()
Delta-Aminovalerianic Acid ()
5-Ammoniopentanoate ()
NSC-73123 ()
5-Amino-Pentanoic Acid ()
5-Aminopentanoic Acid ()
NSC-58383 ()
P&D ID
PD075820
CAS
627-95-2
660-88-8
Tags
available
drug candidate
Drug indication
Discovery agent
Drug Status
investigational
experimental
Max Phase
1.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
29
DESCRIPTION
Weak GABA-B receptor antagonist
(LOPAC library)
DESCRIPTION
5-aminovalerate (or 5-aminopentanoic acid) is a lysine degradation product. It can be produced both endogenously or through bacterial catabolism of lysine. 5-aminovalerate is formed via the following multi-step reaction: L-lysine leads to cadverine leads to L-piperideine leads 5-aminovalerate . In other words it is a metabolite of cadaverine which is formed via the intermediate, 1-piperideine. Cadaverine is a foul-smelling diamine compound produced by protein hydrolysis during putrefaction of animal tissue. High levels of 5-aminovalerate in biofluids may indicate bacterial overgrowth or endogenous tissue necrosis. In most cases endogenous 5-aminovalerate is thought to be primarily a microbial metabolite produced by the gut or oral microflora, although it can be produced endogenously. 5-aminopentanoic acid is an in vivo substrate of 4-aminobutyrate:2-oxoglutarate aminotransferase .
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
ChEMBL Drugs
DrugBank
DrugMAP
DrugMatrix
LOPAC library
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
The Spectrum Collection
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
71
Molecular Weight
117.08
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
0
Aromatic Ring Count
0
cLogP
0.2
TPSA
63.32
Fraction CSP3
0.8
Chiral centers
0.0
Largest ring
0.0
QED
0.52
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
GABA-B
Target
GABA Receptor
Endogenous Metabolite
Pathway
Membrane Transporter/Ion Channel
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Source data
