General
Preferred name
etelcalcetide
Synonyms
AMG 416 ()
Etelcalcetide (hydrochloride) ()
VELCALCETIDE HYDROCHLORIDE ()
VELCALCETIDE ()
AMG 416 (hydrochloride) ()
KAI-4169 (hydrochloride) ()
AMG-416 ()
ONO-5163 ()
Amg416 ()
KAI-4169 ()
Telcalcetide ()
Parsabiv ()
Telcalcetide hydrochloride ()
Etelcalcetide hydrochloride ()
KAI-4169 HCl ()
P&D ID
PD073885
CAS
1262780-97-1
1334237-71-6
Tags
available
drug candidate
drug
Approved by
EMA
FDA
First approval
2017
2016
Drug Status
investigational
approved
Drug indication
Myelodysplastic syndrome
Secondary hyperparathyroidism
Max Phase
Phase 4
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
INDICATION
Etelcalcetide is a calcium-sensing receptor agonist indicated for: ; Secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis.
DESCRIPTION
Etelcalcetide is a novel calcimimetic, peptidic agonist of the human cell surface calcium-sensing receptor (CaSR) . The chemical structure shown here was generated using the SMILES from PubChem CID 71511839.
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Cayman Chemical Bioactives
ChEMBL Approved Drugs
ChEMBL Drugs
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
36
Molecular Weight
1047.53
Hydrogen Bond Acceptors
16
Hydrogen Bond Donors
22
Rotatable Bonds
36
Ring Count
0
Aromatic Ring Count
0
cLogP
-7.23
TPSA
557.71
Fraction CSP3
0.66
Chiral centers
8.0
Largest ring
0.0
QED
0.01
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
CaSR
Pathway
GPCR/G protein
Source data
