General
Preferred name
umifenovir
Synonyms
Umifenovir ()
ARBIDOL ()
Arbidol hydrochloride ()
Arbidol HCl ()
Umifenovir (hydrochloride) ()
Umifenovir hydrochloride, Arbidol hydrochloride ()
Umifenovir hydrochloride ()
Arbidol ()
Umifenovir-d6 (hydrochloride) ()
P&D ID
PD073701
CAS
131707-23-8
5674-91-9
131707-25-0
2928218-29-3
Tags
available
drug
Drug indication
Virus infection
viral disease
Drug Status
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3].
PRICE
50
DESCPRITION
an antiviral agent
DESCRIPTION
Umifenovir is an indole-based antiviral drug. It is a viral entry inhibitor and also acts to modulate the host immune response (induces interferon-production, stimulates macrophages phagocytosis).
(GtoPdb)
DESCRIPTION
Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro[2]. Umifenovir shows anti-inflammatory activity[3].
PRICE
51
DESCRIPTION
Potent and selective herpes simplex virus (HSV) helicase primase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
Umifenovir hydrochloride (Arbidol HCl) , an broad-spectrum antiviral chemical agent, can inhibit cell invade of enveloped viruses by blocking viral fusion with host cell membrane.
(TargetMol Bioactive Compound Library)
DESCRIPTION
Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against enveloped and non-enveloped viruses, suppressing virus propagation and modulating the expression of inflammatory cytokines for use as an anti-influenza virus agent [3]. It effectively inhibits the fusion of the virus with host cells [1] [2] and is an efficient inhibitor of SARS-CoV-2 in vitro [2].
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
8
Compound Sets
18
AdooQ Bioactive Compound Library
Axon Medchem Screening Library
ChEMBL Drugs
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
Guide to Pharmacology
ReFrame library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
50
Molecular Weight
476.08
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
1
Rotatable Bonds
7
Ring Count
3
Aromatic Ring Count
3
cLogP
5.18
TPSA
54.7
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.38
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Influenza A virus
Influenza Virus
SARS-CoV
Antiviral
SARS-CoV-2
CYP3A4
Antiviral agent
CHIKV
Primary Target
Coronaviruses
Indication
influenza A virus infection
MOA
Cytochrome P450 inhibitor
Pathway
Anti-infection
Microbiology/virology
Immunology/Inflammation
Source data
