General
Preferred name
Aminoimidazole carboxamide
Synonyms
4-Amino-5-imidazolecarboxamide ()
AICA ()
5-Aminoimidazole-4-carboxamide ()
orazamide ()
5-Amino-3H-imidazole-4-Carboxamide ()
5-Amino-4-imidazolecarboxamide ()
5-Aminoimidazole-4-carboxamide (hydrate) ()
P&D ID
PD073653
CAS
360-97-4
21299-72-9
Tags
available
drug
Drug Status
approved
investigational
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION 5-Amino-3H-imidazole-4-Carboxamide (AICA) is an important precursor for the synthesis of purines in general and of the nucleobases adenine and guanine in particular[1][2][3].
PRICE 29
DESCRIPTION 5-Amino-3H-imidazole-4-Carboxamide (AICA) is an imidazole derivative and a metabolite of the antineoplastic agents BIC and DIC. It serves as a condensation agent in the preparation of nucleosides and nucleotides, and when compounded with orotic acid, it is used to treat liver diseases. (TargetMol Bioactive Compound Library)
DESCRIPTION 5-Amino-4-imidazolecarboxamide is an imidazole derivative. (TargetMol Bioactive Compound Library)
Compound Sets
9
Cayman Chemical Bioactives
36927
DrugBank
DB06143
DrugCentral
1994
DrugCentral Approved Drugs
1994
MedChem Express Bioactive Compound Library
HY-41461
Other bioactive compounds
ReFrame library
Selleckchem Bioactive Compound Library
4-amino-5-imidazolecarboxamide
TargetMol Bioactive Compound Library
T1705
T1722
External IDs
69
Properties
(calculated by RDKit )
Molecular Weight
126.05
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
-0.91
TPSA
97.79
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
5.0
QED
0.45
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Pathway
Metabolism
Metabolic Enzyme/Protease
Source data