General
Preferred name
INDELOXAZINE
Synonyms
D-YB-119 VII ()
Indeloxazine hydrochloride ()
Indeloxazina ()
Elen ()
YM-08054-1 ()
Indeloxazine hcl ()
CI-874 ()
P&D ID
PD073562
CAS
60929-23-9
104908-37-4
65043-22-3
Tags
available
drug
drug candidate
Drug indication
Dementia
Drug Status
approved
investigational
Max Phase
2.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Indeloxazine hydrochloride acts as a norepinephrine reuptake inhibitor, serotonin releasing agent and NMDA receptor antagonist. It is used as an antidepressant and cerebral activator. It has been found to possess neuroprotective, nootropic, anticonvulsant and antidepressant-like effects in animal models. It could enhance acetylcholine release in the rat forebrain through activation of the 5-HT4 receptor.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
DrugMatrix
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
31
Molecular Weight
231.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
1
cLogP
1.62
TPSA
30.49
Fraction CSP3
0.43
Chiral centers
1.0
Largest ring
6.0
QED
0.86
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Solubility
Soluble in DMSO, not in water
Source data
