General
Preferred name
MITOGUAZONE
Synonyms
MGBG ()
Methyl-GAG ()
Methylglyoxal-bis(guanylhydrazone) ()
Mitoguazona ()
P&D ID
PD073514
CAS
459-86-9
13922-04-8
Tags
available
drug
Drug indication
Neoplasm
Head and neck cancer
Drug Status
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
96
DESCRIPTION
Mitoguazone is a guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Mitoguazone (Methyl-GAG) is a selective S-adenosyl-methionine decarboxylase inhibitor that penetrates the blood-brain barrier and disrupts polyamine biosynthesis. Mitoguazone is a synthetic polycarbonyl derivative with anti-tumor activity that inhibits the integration of HIV DNA into cellular DNA in monocytes and macrophages, inducing apoptosis. Mitoguazone can be used to prevent acute leukemia, Hodgkin lymphoma and non-Hodgkin lymphoma.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
6
Organisms
0
Compound Sets
13
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
NIH Mechanistic Set
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
TargetMol Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
37
Molecular Weight
184.12
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
6
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.69
TPSA
148.52
Fraction CSP3
0.2
Chiral centers
0.0
Largest ring
0.0
QED
0.18
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
HIV-I integrase
S-adenosylmethionine decarboxylase (SAMDC)
Apoptosis
HIV
Member status
member
MOA
Polyamine Biosynthesis Inhibitors
S-Adenosyl-L-methionine Decarboxylase Inhibitors
Pathway
Anti-infection
Microbiology/virology
Proteases/Proteasome
Solubility
In vitro:<br/>10 mM in DMSO
Source data
