General
Preferred name
TROFOSFAMIDE
Synonyms
NSC-109723 ()
Z-4828 ()
Trofosfamida ()
A-4828 ()
P&D ID
PD073029
CAS
22089-22-1
Tags
available
drug
Drug indication
Sarcoma
Non-hodgkin lymphoma
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Trofosfamide is an orally bioavailable oxazaphosphorine derivative with antineoplastic activity[1].
PRICE 29
DESCRIPTION Trofosfamide is a derivative of oxazaphosphorine with antineoplastic potency.
DESCRIPTION Trofosfamide is an orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and tumor cell apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus) (BOC Sciences Bioactive Compounds)
Compound Sets
11
BOC Sciences Bioactive Compounds
trofosfamide-cas-22089-22-1-item-84-174873
Cayman Chemical Bioactives
21874
ChEMBL Drugs
CHEMBL462019
DrugBank
DB12902
DrugCentral
2766
DrugCentral Approved Drugs
2766
DrugMAP
DMHB2C3
DrugMAP Approved Drugs
DMHB2C3
DrugMatrix
MedChem Express Bioactive Compound Library
HY-119824
ReFrame library
External IDs
23
Properties
(calculated by RDKit )
Molecular Weight
322.02
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
7
Ring Count
1
Aromatic Ring Count
0
cLogP
2.84
TPSA
32.78
Fraction CSP3
1.0
Chiral centers
1.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Bacterial
Pathway
Anti-infection
Source data