General
Preferred name
BELOTECAN
Synonyms
CKD 602 ()
BELOTECAN HYDROCHLORIDE ()
Camtobell ()
CKD602 ()
Belotecan (hydrochloride) ()
CKD-602 ()
CKD-602 (free base) ()
Belotecan (CKD-602) hydrochloride ()
Belotecan hcl ()
Belotecan (hydrochloride) ()
P&D ID
PD072532
CAS
256411-32-2
213819-48-8
Tags
available
drug candidate
drug
Approved by
KFDA
First approval
2003
Drug indication
small cell lung carcinoma
Lung cancer
Solid tumour/cancer
Drug Status
approved
investigational
Max Phase
2.0
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Belotecan (CKD-602 free base) is a DNA topoisomerase I inhibitor. Belotecan induces cell apoptosis and cell-cycle arrest. Belotecan is a camptothecin analogue with anti-tumor effects, it can be used for the research of cancer[1].
DESCRIPTION
Belotecan hydrochloride (CKD-602 hydrochloride), a Topoisomerase I inhibitor, is a synthetic camptothecin derivative.
PRICE
93
DESCRIPTION
Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activity
DESCRIPTION
Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Suppressor of MDK expression; inhibits PI 3-K signaling
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Natural product-based probes and drugs
ReFrame library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
46
Molecular Weight
433.2
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
3
cLogP
2.62
TPSA
93.45
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
DNA Topoisomerases
MOA
Inhibitor
Topoisomerase inhibitor
Biosynthetic Origin
Alkaloid
Therapeutic Indication
Anticancer
Target
Topoisomerase
Apoptosis
Pathway
Cell Cycle/DNA Damage
Source data
