General
Preferred name
BELOTECAN
Synonyms
CKD 602 ()
BELOTECAN HYDROCHLORIDE ()
Camtobell ()
CKD602 ()
Belotecan (hydrochloride) ()
CKD-602 ()
Belotecan (CKD-602) hydrochloride ()
Belotecan hcl ()
Belotecan (hydrochloride) ()
P&D ID
PD072532
CAS
256411-32-2
213819-48-8
Tags
drug candidate
natural product
drug
available
Approved by
KFDA
First approval
2003
Drug indication
Solid tumour/cancer
Drug Status
investigational
approved
Max Phase
Phase 2
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Belotecan binds to and inhibits the activity of topoisomerase I, stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Suppressor of MDK expression; inhibits PI 3-K signaling
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
14
AdooQ Bioactive Compound Library
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
MedChem Express Bioactive Compound Library
Natural product-based probes and drugs
ReFrame library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
43
Properties
(calculated by RDKit )
Molecular Weight
433.2
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
5
Aromatic Ring Count
3
cLogP
2.62
TPSA
93.45
Fraction CSP3
0.4
Chiral centers
1.0
Largest ring
6.0
QED
0.47
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Primary Target
DNA Topoisomerases
MOA
Inhibitor
Topoisomerase inhibitor
Biosynthetic Origin
Alkaloid
Therapeutic Indication
Anticancer
Pathway
Cell Cycle/DNA Damage
Target
Topoisomerase
Source data