General
Preferred name
MELARSOPROL
Synonyms
RP-3854 ()
Mel b ()
RP 3854 ()
P&D ID
PD072329
CAS
494-79-1
Tags
available
prodrug
drug
Drug indication
Trypanosomiasis
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Melarsoprol, a melaminophenylarsine-type trivalent organic arsenical, is an important drug for African trypanosomiasis. Melarsoprol is also active against leukemia cell lines and plasma cells from myeloma patients. Melarsoprol increases the biliary output of GSH in rats[1].
Cell lines
4
Organisms
8
Compound Sets
8
ChEMBL Drugs
CHEMBL166
DrugBank
DB12864
DrugCentral
3336
DrugCentral Approved Drugs
3336
DrugMAP
DMGUZ0W
DrugMAP Approved Drugs
DMGUZ0W
MedChem Express Bioactive Compound Library
HY-119594
ReFrame library
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
398.0
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
4
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
2
cLogP
0.32
TPSA
122.97
Fraction CSP3
0.25
Chiral centers
2.0
Largest ring
6.0
QED
0.54
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Apoptosis
Parasite
Pathway
Anti-infection
Source data