General
Preferred name
ARTENIMOL
Synonyms
¦Â-Dihydroartemisinin ()
DHA ()
β-Dihydroartemisinin ()
Dihydroqinghaosu ()
??Dihydroartemisinin ()
Dihydroartemisinin ()
Arteminol ()
Artenimol component of eurartesim dihydroartemisinin ()
Artenimolum ()
Di-hydroqinghaosu ()
Cotexin ()
Artemether related compound a ()
GNF-Pf-5634 ()
.beta.-dihydroartemisinin ()
Cotecxin ()
Dynamax ()
Dihydroartemisinine ()
Santecxin ()
Salaxin ()
Dihydroartemisinin, .beta.- ()
Alaxin ()
P&D ID
PD072171
CAS
71939-50-9
Tags
available
drug
natural product
Approved by
EMA
First approval
2011
Drug indication
Malaria
Drug Status
approved
experimental
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Artenimol is the active metabolite of and all artemisinin-derived antimalarial compounds. The metabolite itself is used in formulations to treat malaria as part of an artemisinin-based combination therapy (ACT).
We show one representation of artenimol here. As with other natural products, there are alternative chemical structures due to the complex stereochemistry.
Artenimol is listed in the WHO 20th Essential Medicines List (2017) as an antimalarial for curative treatment in combination with . This is one of the ACT recommended in the WHO Guidelines for the treatment of malaria .
Potential Target/Mechanism Of Action: As the precise mechanism of action of artenimol is not yet known, we do not have a molecular target for this compound.
We show one representation of artenimol here. As with other natural products, there are alternative chemical structures due to the complex stereochemistry.
Artenimol is listed in the WHO 20th Essential Medicines List (2017) as an antimalarial for curative treatment in combination with . This is one of the ACT recommended in the WHO Guidelines for the treatment of malaria .
Potential Target/Mechanism Of Action: As the precise mechanism of action of artenimol is not yet known, we do not have a molecular target for this compound.
DESCRIPTION
Artenimol is the active metabolite of and all artemisinin-derived antimalarial compounds.
We show one representation of artenimol here. As with other natural products, there are alternative chemical structures due to the complex stereochemistry.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
We show one representation of artenimol here. As with other natural products, there are alternative chemical structures due to the complex stereochemistry.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
DESCRIPTION
Artenimol is the active metabolite of and all artemisinin-derived antimalarial compounds. The metabolite itself is used in formulations to treat malaria as part of an artemisinin-based combination therapy (ACT).
We show one representation of artenimol here. As with other natural products, there are alternative chemical structures due to the complex stereochemistry.
Artenimol is listed in the WHO 20th Essential Medicines List (2017) as an antimalarial for curative treatment in combination with piperaquine. This is one of the ACT recommended in the WHO Guidelines for the treatment of malaria .
Potential Target/Mechanism Of Action: As the precise mechanism of action of artenimol is not yet known, we do not have a molecular target for this compound.
We show one representation of artenimol here. As with other natural products, there are alternative chemical structures due to the complex stereochemistry.
Artenimol is listed in the WHO 20th Essential Medicines List (2017) as an antimalarial for curative treatment in combination with piperaquine. This is one of the ACT recommended in the WHO Guidelines for the treatment of malaria .
Potential Target/Mechanism Of Action: As the precise mechanism of action of artenimol is not yet known, we do not have a molecular target for this compound.
DESCRIPTION
Dihydroartemisinin is a potent anti-malaria agent.
PRICE
29
DESCRIPTION
Dihydroartemisinin (Artenimol) is a metabolite of artemisinin.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
73
Organisms
8
Compound Sets
12
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
ReFrame library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
22
Molecular Weight
284.16
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
5
Aromatic Ring Count
0
cLogP
2.19
TPSA
57.15
Fraction CSP3
1.0
Chiral centers
8.0
Largest ring
7.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
NF-¦ÊB
NF-??
Parasite
Pathway
Apoptosis
Autophagy
Microbiology/virology
NF-κB
Anti-infection
Indication
malaria
MOA
antimalarial agent
Source data
