General
Preferred name
NAPROXCINOD
Synonyms
4-(NITROOXY)BUTYL (2S)-2-(6-METHOXY-2-NAPHTHYL)PROPANOATE ()
Naproxen-n-butyl nitrate ()
HCT3012 ()
HCT 3012 ()
HCT-3012 ()
AZD-3582 ()
AZD3582 ()
Nitronaproxen ()
AR-P900758XX ()
P&D ID
PD071969
CAS
163133-43-5
Tags
available
prodrug
drug
Drug indication
rheumatic disease
Inflammation
Drug Status
approved
investigational
Max Phase
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Naproxcinod is a NO-donating analogue prodrug. It is the first in a new class of anti-inflammatory and analgesic drugs known as cyclooxygenase-inhibiting nitric oxide donors (CINODs) , that are designed to lessen the gastrointestinal (and cardiovascular) side-effects of traditional NSAIDs. The NO released by the prodrug mediates this beneficial effect.
(GtoPdb)
DESCRIPTION
Naproxcinod, a nitro compound, has been found to be a nitric oxide donor as well as a cyclooxygenase inhibitor that was once studied aginast duchenne muscular dystrophy.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
ChEMBL Drugs
DrugBank
DrugCentral
DrugCentral Approved Drugs
DrugMAP
Guide to Pharmacology
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
27
Molecular Weight
347.14
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
9
Ring Count
2
Aromatic Ring Count
2
cLogP
3.48
TPSA
87.9
Fraction CSP3
0.39
Chiral centers
1.0
Largest ring
6.0
QED
0.3
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
