General
Preferred name
VOCLOSPORIN
Synonyms
ISAtx-247 ()
P&D ID
PD071821
CAS
515814-01-4
368455-04-3
515814-00-3
Tags
available
PROTAC
drug
Approved by
EMA
FDA
First approval
2021
Drug Status
investigational
approved
Drug indication
Lupus nephritis
Psoriasis vulgaris
Kidney disease
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCPRITION
semi-synthetic cyclosporine A analog & calcineurin inhibitor
DESCRIPTION
Voclosporin (ISA247, ISATX247) is a cyclic peptide that is a semi-synthetic cyclosporine analogue , but with distinct clinical efficacy and safety profiles . Like cyclosporine, it has immunosuppressive action, and it binds cyclophilin A . Functionally, it acts as a calcineurin inhibitor. Prior to voclosporin, clinically used calcineurin inhibitors were cyclosporine (), , and .
(GtoPdb)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
11
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NCATS Inxight Approved Drugs
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
21
Molecular Weight
1213.84
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
5
Rotatable Bonds
16
Ring Count
1
Aromatic Ring Count
0
cLogP
3.44
TPSA
278.8
Fraction CSP3
0.76
Chiral centers
12.0
Largest ring
33.0
QED
0.14
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
calcineurin inhibitor
Pathway
Metabolic Enzyme/Protease
Target
Molecular Glues
phosphatase
Source data
