General
Preferred name
ESTRADIOL ACETATE
Synonyms
Estradiol-3-Acetate ()
Femtrace ()
Femring ()
Estradiol 3-acetate ()
E3A ()
P&D ID
PD071779
CAS
4245-41-4
Tags
drug
Approved by
FDA
First approval
2003
Drug indication
Atrophy
Hormone replacement therapy
Drug Status
vet_approved
approved
investigational
Max Phase
4.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.; ; Increases in the down-stream effects of ER binding reverses some of the symptoms of menopause, which are primarily caused by a loss of estrogenic activity.
Compound Sets
9
ChEMBL Approved Drugs
CHEMBL1200430
ChEMBL Drugs
CHEMBL1200430
Drug Repurposing Hub
DrugBank
DB13952
DrugBank Approved Drugs
DB13952
DrugCentral
4497
DrugCentral Approved Drugs
4497
DrugMAP
DM07U2A
DrugMAP Approved Drugs
DM07U2A
External IDs
26
Properties
(calculated by RDKit )
Molecular Weight
314.19
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
4
Aromatic Ring Count
1
cLogP
3.83
TPSA
46.53
Fraction CSP3
0.65
Chiral centers
5.0
Largest ring
6.0
QED
0.63
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Disease Area
endocrinology, obstetrics/gynecology
Indication
menopause, vaginal atrophy
Target
ESR1
MOA
Estrogen receptor agonist
Source data