General
Preferred name
ETOPOSIDE PHOSPHATE
Synonyms
BMY-40481 ()
Vepeside ()
VP16 ()
Etopophos preservative free ()
VP-16 ()
Etopophos ()
BMY 40481 ()
P&D ID
PD071729
CAS
117091-64-2
Tags
prodrug
natural product
drug
available
Approved by
FDA
First approval
1996
Drug Status
approved
Max Phase
Phase 4
Drug indication
Antineoplastic
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Etoposide Phosphate is a derivative of Etoposide. Etoposide is a topoisomerase II inhibitor that is widely used as an apoptosis inducer. Etoposide exhibits antineoplastic and anti-mitotic properties. It inhibits DNA synthesis and induces double-strand and single-strand DNA breaks.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
BOC Sciences Bioactive Compounds
ChEMBL Approved Drugs
ChEMBL Drugs
Drug Repurposing Hub
DrugCentral
DrugCentral Approved Drugs
MedChem Express Bioactive Compound Library
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
668.15
Hydrogen Bond Acceptors
14
Hydrogen Bond Donors
4
Rotatable Bonds
7
Ring Count
7
Aromatic Ring Count
2
cLogP
1.1
TPSA
207.36
Fraction CSP3
0.55
Chiral centers
10.0
Largest ring
6.0
QED
0.24
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Indication
testicular carcinoma, small cell lung cancer
Target
TOP2A
Bacterial
Topoisomerase
MOA
Topoisomerase inhibitor
Pathway
Anti-infection
Apoptosis
Autophagy
Cell Cycle/DNA Damage
Source data
