General
Preferred name
PIPERAQUINE
Synonyms
Piperaquine tetraphosphate tetrahydrate ()
Piperaquine (phosphate) ()
Piperaquine (tetraphosphate tetrahydrate) ()
PIPERAQUINE PHOSPHATE ()
PIPERAQUINE TETRAPHOSPHATE ()
Piperaquinoline ()
Piperaquine phosphate component of eurartesim piperaquine tetraphosphate ()
P&D ID
PD071703
CAS
915967-82-7
4085-31-8
85547-56-4
Tags
available
drug
drug candidate
Approved by
EMA
First approval
2011
Drug indication
Plasmodium vivax malaria
Malaria
Drug Status
approved
experimental
investigational
Max Phase
2.0
1.0
3.0
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Piperaquine is listed in the WHO 20th Essential Medicines List (2017) as an antimalarial for curative treatment in combination with . This is one of the ACT recommended in the WHO Guidelines for the treatment of malaria .
Potential Target/Mechanism Of Action:
Piperaquine is listed in the WHO 20th Essential Medicines List (2017) as an antimalarial for curative treatment in combination with . This is one of the ACT recommended in the WHO Guidelines for the treatment of malaria .
Potential Target/Mechanism Of Action:
DESCRIPTION
Piperaquine is a 4-aminoquinoline antimalarial compound.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. (GtoPdb)
DESCRIPTION
Piperaquine tetraphosphate tetrahydrate is a potent anti-parasites agent.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
3
Compound Sets
14
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugCentral
DrugCentral Approved Drugs
DrugMAP
DrugMAP Approved Drugs
Guide to Pharmacology
ReFrame library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
60
Molecular Weight
534.21
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
6
Aromatic Ring Count
4
cLogP
5.42
TPSA
38.74
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
6.0
QED
0.33
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Parasite
Indication
malaria
MOA
antimalarial agent
Pathway
Microbiology/virology
Anti-infection
Source data
