General
Preferred name
CEVIMELINE
Synonyms
Cevimeline hydrochloride ()
Cevimelina ()
Cevimeline ()
AF102B ()
Cevimeline hydrochloride hemihydrate ()
Cevimeline hydrochloride hydrate ()
SNK-508 ()
AF-102B ()
Evoxac ()
SNI-2011 ()
SND-5008 ()
Cevimeline hcl ()
FKS-508 ()
Saligren ()
P&D ID
PD071688
CAS
107220-28-0
107233-08-9
153504-70-2
Tags
available
drug
Approved by
FDA
First approval
2000
Drug Status
approved
Max Phase
4.0
Drug indication
Xerostomia
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Cevimeline is an orally administered cholinergic analogue with parasympathomimetic activity. The INN is a mixture of enantiomers. We show the structure without stereochemistry to represent the mixture. (GtoPdb)
PRICE 230
DESCRIPTION Cevimeline hydrochloride hemihydrate is a novel muscarinic receptor agonist, used as a candidate therapeutic drug for xerostomia in Sjogren's syndrome.
Compound Sets
12
CeMM library of unique drugs (CLOUD)
ChEMBL Approved Drugs
CHEMBL168815
CHEMBL2218917
ChEMBL Drugs
CHEMBL168815
CHEMBL2218917
DrugCentral
584
DrugCentral Approved Drugs
584
DrugMatrix
Guide to Pharmacology
9658
LSP-MoA library (Laboratory of Systems Pharmacology)
CHEMBL168815
Mcule NIBR MoA Box Subset
MCULE-2587668307
Novartis Chemogenetic Library (NIBR MoA Box)
Other bioactive compounds
ReFrame library
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
199.1
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
0
Rotatable Bonds
0
Ring Count
4
Aromatic Ring Count
0
cLogP
1.56
TPSA
12.47
Fraction CSP3
1.0
Chiral centers
2.0
Largest ring
6.0
QED
0.59
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
muscarinic acetylcholine receptor agonist
CHRM1 agonist
Target
Muscarinic acetylcholine receptor M1
Muscarinic acetylcholine receptor M3
Member status
virtual
Source data