General
Preferred name
PIK-III
Synonyms
Vps34-PIK-III ()
VPS34-IN2 ()
P&D ID
PD071608
CAS
1383716-40-2
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Vps34-PIK-III is an orally active and selective VPS34 inhibitor (IC50=18 nM). Vps34-PIK-III effectively inhibits autophagy and can be used as a molecular tool. vps34-PIK-III is also a PI3K inhibitor that inhibits the expression of genes in liver cancer stem cells (CSCs)[1][2][3].
PRICE 144
DESCRIPTION PIK-III is a selective inhibitor of VPS34 (PIK3C3) . PIK-III is used as a tool compound to investigate the role of VPS34 in autophagy and cellular homeostasis.

SARS-CoV-2: PIK-III has been used in vitro to establish that VPS34 is required for SARS-CoV-2 replication . (GtoPdb)
DESCRIPTION Vps34-PIK-III (VPS34-IN2), a selective inhibitor of VPS34 enzymatic activity, inhibits autophagy and results in the stabilization of autophagy substrates. (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
1
Compound Sets
8
AdooQ Bioactive Compound Library
A15868
Cayman Chemical Bioactives
17002
EU-OPENSCREEN Bioactive Compound Library
EOS100279
Guide to Pharmacology
9379
MedChem Express Bioactive Compound Library
HY-12794
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
pik-iii
TargetMol Bioactive Compound Library
T6945
External IDs
14
Properties
(calculated by RDKit )
Molecular Weight
319.15
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
2
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
3
cLogP
2.61
TPSA
102.5
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.74
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Member status
member
MOA
Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 (PIK3C3
Vps34) Inhibitors
Pathway
Autophagy
PI3K/Akt/mTOR signaling
PI3K/Akt/mTOR
Target
PI3K
Autophagy,LC3,PI3K
PI3Kα
PI3Kβ
PI3Kγ
PI3Kδ
Vps34
Source data