General
Preferred name
NVP-TNKS656
Synonyms
TNKS656 ()
NVP-TNKS-656 ()
NVP‐TNKS656 ()
P&D ID
PD071440
CAS
1419949-20-4
Tags
available
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM, and is > 300 fold selectivity against PARP1 and PARP2.
PRICE 129
DESCRIPTION NVP‐TNKS656 is a potent and selective inhibitor of the poly(ADP-ribose) polymerase (PARP) tankyrase enzymes, that was designed by Novartis for anti-tumour potential . It is active in vivo. (GtoPdb)
DESCRIPTION NVP-TNKS656 (TNKS656) is a highly potent, selective, and orally active TNKS2 inhibitor. (TargetMol Bioactive Compound Library)
Compound Sets
11
Axon Medchem Screening Library
2599
Cayman Chemical Bioactives
19930
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
EU-OPENSCREEN Bioactive Compound Library
EOS100307
EUbOPEN Chemogenomics Library
EUB0002668
Guide to Pharmacology
10674
MedChem Express Bioactive Compound Library
HY-13990
Novartis Chemogenetic Library (NIBR MoA Box)
Selleckchem Bioactive Compound Library
nvp-tnks656
TargetMol Bioactive Compound Library
T3261
External IDs
18
Properties
(calculated by RDKit )
Molecular Weight
494.25
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
1
Rotatable Bonds
9
Ring Count
5
Aromatic Ring Count
2
cLogP
2.18
TPSA
104.83
Fraction CSP3
0.56
Chiral centers
0.0
Largest ring
6.0
QED
0.53
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
Apoptosis
PARP
TNKS2
Wnt/TNKS inhibitor
Member status
member
MOA
Tankyrase 1 (TNKS1
PARP5A) Inhibitors
Tankyrase 2 (TNKS2
PARP5B) Inhibitors
tankyrase inhibitor
Pathway
Chromatin/Epigenetic
Cytoskeletal Signaling
DNA Damage/DNA Repair
Stem Cells
Cell Cycle/DNA Damage
Epigenetics
Recommended Cell Concentration
None
Source data