General
Preferred name
TILARGININE
Synonyms
NG-Monomethyl-L-arginine acetate ()
Methylarginine acetate ()
L-NMMA acetate ()
TILARGININE ACETATE ()
L-NMMA (acetate) ()
L-Ornithine, N5-[imino(methylamino)methyl]- ()
Tilarginine (acetate) ()
Methylarginine (acetate) ()
Tilarginine Acetate, Methylarginine acetate, NG-Monomethyl-L-arginine acetate, L-NG-monomethyl Arginine acetate, ()
Ng-methylarginine acetate ()
Ng-methyl-l-arginine acetate salt ()
ANO-1020 ()
Targinine acetate ()
L-NMMA ()
Ng-methylarginine ()
Targinine ()
Ng-monomethyl-l-arginine ()
Omega-n-methylated arginine ()
Omega-n-methylarginine ()
.omega.-n-methylarginine ()
L-NMMA (citrate) ()
P&D ID
PD071370
CAS
53308-83-1
17035-90-4
Tags
drug candidate
natural product
drug
available
Drug Status
investigational
approved
Drug indication
Angina pectoris
Myocardial infarction
Max Phase
Phase 3
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tilarginine acts as a pan-nitric oxide synthase (NOS) inhibitor. Chemically it is a conformationally restricted arginine analogue . It was investigated for potential immunomodulating and antineoplastic activities.
(GtoPdb)
DESCRIPTION
Nitric oxide synthase inhibitor; blocks formation of endothelium-derived relaxing factor (EDRF)
(LOPAC library)
DESCRIPTION
PARP inhibitor
(Tocris Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
4
Organisms
2
Compound Sets
13
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
DrugBank Approved Drugs
DrugMAP
Guide to Pharmacology
LOPAC library
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
ReFrame library
Selleckchem Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
82
Properties
(calculated by RDKit )
Molecular Weight
188.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
5
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.08
TPSA
111.23
Fraction CSP3
0.71
Chiral centers
1.0
Largest ring
0.0
QED
0.21
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
NOS
Primary Target
Non-selective NOS
MOA
Inhibitor
nitric oxide synthase inhibitor
Target
NOS3
Endogenous Metabolite
NO Synthase
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Source data