General
Preferred name
TILARGININE
Synonyms
NG-Monomethyl-L-arginine acetate ()
Methylarginine acetate ()
L-NMMA acetate ()
TILARGININE ACETATE ()
L-Ornithine, N5-[imino(methylamino)methyl]- ()
L-NMMA (acetate) ()
Tilarginine (acetate) ()
Methylarginine (acetate) ()
Tilarginine Acetate, Methylarginine acetate, NG-Monomethyl-L-arginine acetate, L-NG-monomethyl Arginine acetate, ()
L-NMMA (citrate) ()
Targinine acetate ()
Ng-methyl-l-arginine acetate salt ()
ANO-1020 ()
Ng-methylarginine acetate ()
Omega-n-methylated arginine ()
L-NMMA ()
Tilarginina ()
Ng-monomethyl-l-arginine ()
Omega-n-methylarginine ()
Ng-methylarginine ()
.omega.-n-methylarginine ()
P&D ID
PD071370
CAS
53308-83-1
17035-90-4
Tags
available
drug candidate
drug
Drug indication
anemia (phenotype)
Angina pectoris
Myocardial infarction
Shock
Drug Status
approved
investigational
Max Phase
3.0
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Tilarginine acts as a pan-nitric oxide synthase (NOS) inhibitor. Chemically it is a conformationally restricted arginine analogue . It was investigated for potential immunomodulating and antineoplastic activities. (GtoPdb)
DESCRIPTION PARP inhibitor (Tocris Bioactive Compound Library)
DESCRIPTION Nitric oxide synthase inhibitor; blocks formation of endothelium-derived relaxing factor (EDRF) (LOPAC library)
Cell lines
6
Organisms
2
Compound Sets
13
Cayman Chemical Bioactives
80200
10005031
ChEMBL Drugs
CHEMBL1256175
CHEMBL256147
Drug Repurposing Hub
DrugBank
DB11815
DrugBank Approved Drugs
DB11815
DrugMAP
DMZBGI8
Guide to Pharmacology
11467
LOPAC library
MedChem Express Bioactive Compound Library
HY-18732A
NIH Clinical Collections (NCC)
ReFrame library
Selleckchem Bioactive Compound Library
l-nmma-acetate
Tocris Bioactive Compound Library
0771
External IDs
87
Properties
(calculated by RDKit )
Molecular Weight
188.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
5
Rotatable Bonds
5
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.08
TPSA
111.23
Fraction CSP3
0.71
Chiral centers
1.0
Largest ring
0.0
QED
0.21
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
NOS
Primary Target
Non-selective NOS
MOA
Inhibitor
nitric oxide synthase inhibitor
Target
NOS3
Endogenous Metabolite
NO Synthase
Pathway
Immunology/Inflammation
Metabolic Enzyme/Protease
Source data