General
Preferred name
UH-232
Synonyms
(+)-UH 232 maleate ()
P&D ID
PD071367
CAS
95999-12-5
1217473-50-1
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
D2-like autoreceptor antagonist. D3 partial agonist.
(Tocriscreen Total)
DESCRIPTION
(+)-UH 232 maleate is a dopamine D2 antagonist (Ki = 72.7 nM in a ligand binding assay; apparent KB = 14.5 nM in a cAMP accumulation assay) that preferentially effects on central dopamine autoreceptors. (+)-UH 232 maleate significantly promotes dopamine synthesis and turnover. (+)-UH 232 maleate is also a dopamine D3 partial agonist.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
5
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
DrugMAP
ReFrame library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
275.22
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
6
Ring Count
2
Aromatic Ring Count
1
cLogP
4.24
TPSA
12.47
Fraction CSP3
0.67
Chiral centers
2.0
Largest ring
6.0
QED
0.77
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
DRD2, DRD3, DRD4, HTR1A
MOA
Dopamine Receptor antagonist
Source data
