General
Preferred name
Cucurbitacin IIb
Synonyms
CuIIb, Dihydrocucurbitacin F, 25-deacetyl hemslecin A ()
P&D ID
PD071349
CAS
50298-90-3
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Cucurbitacin IIb is an active component isolated from Hemsleya amabilis, induces apoptosis with anti-inflammatory activity. Cucurbitacin IIb inhibits phosphorylation of STAT3, JNK and Erk1/2, enhances the phosphorylation of I¦ÊB and NF-¦ÊB (p65), blocks nuclear translocation of NF-¦ÊB (p65) and decreases mRNA levels of I¦ÊB¦Á and TNF-¦Á[1].
PRICE
384
DESCRIPTION
1. Cucurbitacin IIb is one of the major active compounds in Hemsleyadine tablets which have been used for clinical treatment of bacillary dysentery, enteritis and acute tonsilitis. 2. Cucurbitacin IIb exhibits its anti-inflammatory activity through modulating multiple cellular behaviors and signaling pathways, leading to the suppression of the adaptive immune response.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
3
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
13
Molecular Weight
520.34
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
5
Rotatable Bonds
5
Ring Count
4
Aromatic Ring Count
0
cLogP
2.94
TPSA
135.29
Fraction CSP3
0.87
Chiral centers
10.0
Largest ring
6.0
QED
0.35
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Apoptosis
Apoptosis related,ERK,I¦ÊB/IKK,JNK,NF-¦ÊB,STAT,TNF-alpha
Source data
