General
Preferred name
PD071258
Synonyms
H-9 DIHYDROCHLORIDE ()
H 9 Dihydrochloride ()
N-(2-aminoethyl)isoquinoline-5-sulfonamide ()
H-9 (Dihydrochloride) ()
H-9 (hydrochloride) ()
P&D ID
PD071258
CAS
84468-17-7
116970-50-4
116700-36-8
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION H-9 Dihydrochloride is a PKA (protein kinase) inhibitor. H-9 Dihydrochloride (10 ¦ÌM) significantly reduces the excitatory response to 5-HT. H-9 Dihydrochloride also has a direct effect on pharyngeal activity. H-9 Dihydrochloride inhibits signal-transduction and cell growth in EGF (epidermal growth factor)-dependent epithelial cell lines[1][2][3].
PRICE 74
DESCRIPTION H-9 dihydrochloride is a protein kinase inhibitor. It inhibits PKA (Ki = 1.9 μM), PKG (Ki = 0.9 μM), CaMK II (Ki = 60 μM), PKC (Ki = 18 μM), casein kinase I (Ki = 110 μ M) and casein kinase II (Ki > 300 μM). H-9 hydrochloride reduces the cAMP-mediated excitatory response to serotonin in C. elegans enteric neurons2 and inhibits PKA-mediated phosphorylation in a rat seizure model. (BOC Sciences Bioactive Compounds)
DESCRIPTION H-9 dihydrochloride is a potent protein kinase (PKA) inhibitor.H-9 Dihydrochloride significantly reduces the excitatory response to 5-HT at low concentrations.H-9 Dihydrochloride affects pharyngeal activity.H-9 Dihydrochloride inhibits signaling and cell growth of EGF ( H-9 Dihydrochloride inhibits EGF (epidermal growth factor)-dependent signaling and cell growth in epithelial cell lines. (TargetMol Bioactive Compound Library)
DESCRIPTION Shows inhibitory activity against cyclic nucleotide-dependent protein kinase (Ki = 0.87 µM for PKG and Ki = 1.9µM for PKA) and protein kinase C (Ki = 18 µM). (Enamine Bioactive Compounds)
Cell lines
0
Organisms
1
Compound Sets
10
BOC Sciences Bioactive Compounds
h-9-dihydrochloride-cas-116700-36-8-item-70824
Cayman Chemical Bioactives
13312
DrugMAP
DMG2MSX
DrugMatrix
Enamine Bioactive Compounds
EBC-44083
Enamine BioReference Compounds
EU-OPENSCREEN Bioactive Compound Library
EOS101938
MedChem Express Bioactive Compound Library
HY-100923
Novartis Chemogenetic Library (NIBR MoA Box)
TargetMol Bioactive Compound Library
T22833
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
251.07
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
2
Rotatable Bonds
4
Ring Count
2
Aromatic Ring Count
2
cLogP
0.47
TPSA
85.08
Fraction CSP3
0.18
Chiral centers
0.0
Largest ring
6.0
QED
0.83
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
PKA
5-HT
EGFR
5-HT Receptor
Member status
virtual
MOA
cAMP-Dependent Protein Kinase (PKA) Inhibitors
Inhibitors of Signal Transduction Pathways
Pathway
GPCR/G protein
JAK/STAT Signaling
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
TGF-beta/Smad
Angiogenesis
Neuroscience
Tyrosine Kinase/Adaptors
Source data