General
Preferred name
PD071245
Synonyms
4-Chlorophenylguanidine hydrochloride ()
4-Chlorophenylguanidine (hydrochloride) ()
N-(4-Chlorophenyl)guanidine hydrochloride ()
P&D ID
PD071245
CAS
14279-91-5
45964-97-4
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
4-Chlorophenylguanidine hydrochloride is a potent ASIC3 positive allosteric modulator and reverses the effects of ASIC3 desensitization. 4-Chlorophenylguanidine hydrochloride influences ASIC3 activity through directly activating the channel and increasing proton sensitivity. 4-Chlorophenylguanidine hydrochloride offers a chemical backbone for the design of new ASIC3 ligands to study ASIC3 in vivo[1].
PRICE
29
DESCRIPTION
Urokinase inhibitor
(Tocriscreen Total)
DESCRIPTION
Aromatic L-amino acid decarboxylase inhibitor
(Tocris Bioactive Compound Library)
DESCRIPTION
4-Chlorophenylguanidine hydrochloride is the hydrochloride salt of chlorophenylguanidine, which is a specific and potent inhibitor of urokinase. It is a useful reagent in the synthesis of pyrimidine derivatives. It may be a potential target for cancer treatment.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
N-(4-Chlorophenyl)guanidine is a specific and potent inhibitor of urokinase. IT also inhibits 5-hydroxytryptamine receptor 3a.
(Enamine Bioactive Compounds)
DESCRIPTION
4-Chlorophenylguanidine hydrochloride is a potent and selective inhibitor of urokinase.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
9
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
DrugMatrix
Enamine Bioactive Compounds
Enamine BioReference Compounds
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
169.04
Hydrogen Bond Acceptors
1
Hydrogen Bond Donors
3
Rotatable Bonds
1
Ring Count
1
Aromatic Ring Count
1
cLogP
1.65
TPSA
61.9
Fraction CSP3
0.0
Chiral centers
0.0
Largest ring
6.0
QED
0.44
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
urokinase
PLAUR
Sodium Channel
Primary Target
Urokinase
MOA
Inhibitor
urokinase inhibitor
Pathway
Membrane Transporter/Ion Channel
Source data
