General
Preferred name
(-)-U-50488
Synonyms
(-)-U-50488 hydrochloride ()
(-)-trans-(1S,2S)-U-50488 hydrochloride ()
(±) trans-U-50488 methanesulfonate ()
(+/-)-TRANS-U-50488 METHANESULFONATE ()
NCG-C00094503-01 ()
(-)-Trans-(1S,2S)-U-50488 HCl ()
(-)-U-50488 CHLORIDE ()
(-)-U-50488 METHANE SULFONATE ()
(-)-U-50488H ()
P&D ID
PD071235
CAS
114528-79-9
Tags
drug candidate
natural product
available
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
GPR3 agonist; also inhibits NOS and NADPH oxidases
(Tocris Bioactive Compound Library)
DESCRIPTION
Standard selective kappa agonist. More active enantiomer of (+/-)-U-50488 (Cat. No. 0495)
(Tocriscreen Plus)
DESCRIPTION
Potent kappa opioid receptor agonist; more potent enantiomer of (±)-trans-U-50488
(LOPAC library)
DESCRIPTION
Standard selective κ agonist. More active enantiomer of (±)-U-50488 (Cat. No. 0495)
(Tocriscreen Total)
DESCRIPTION
(-)-U-50488 hydrochloride is the more active enantiomer of (±)-U-50488, which is an opioid receptor agonist.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
Selective kappa opioid receptor agonist.
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
8
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
DrugMAP
LOPAC library
Other bioactive compounds
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
28
Molecular Weight
368.14
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
1
cLogP
4.4
TPSA
23.55
Fraction CSP3
0.63
Chiral centers
2.0
Largest ring
6.0
QED
0.79
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
7-TM Receptors
Selectivity
kappa
Primary Target
? Opioid Receptors
MOA
Agonist
Opioid Receptor agonist
Target
OPRK1
Source data
