General
Preferred name
CIDOXEPIN
Synonyms
DOXEPIN HYDROCHLORIDE ()
CIDOXEPIN HYDROCHLORIDE ()
Doxepin cis-form hydrochloride ()
Cidoxepin hcl ()
Doxepin hydrochloride, (z)- ()
P-4599 ()
Doxepin, (z)- ()
Doxepin trans-form hydrochloride ()
Doxepin (hydrochloride) ()
P&D ID
PD071231
CAS
1229-29-4
4698-39-9
25127-31-5
3607-18-9
1668-19-5
Tags
drug candidate
natural product
available
Drug indication
Antidepressant
Drug Status
experimental
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Highly potent H1 antagonist. Also binds to H4 receptor
(Tocriscreen Total)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
8
Cayman Chemical Bioactives
ChEMBL Drugs
Drug Repurposing Hub
DrugBank
NIH Clinical Collections (NCC)
Novartis Chemogenetic Library (NIBR MoA Box)
The Spectrum Collection
Tocriscreen Total
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
279.16
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
0
Rotatable Bonds
3
Ring Count
3
Aromatic Ring Count
2
cLogP
3.96
TPSA
12.47
Fraction CSP3
0.26
Chiral centers
0.0
Largest ring
7.0
QED
0.84
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Member status
member
MOA
Histamine H1 Receptor Antagonists
Histamine H2 Receptor Antagonists
5-HT Reuptake Inhibitors
Norepinephrine Reuptake Inhibitors
Histamine Receptor antagonist
Indication
depression, anxiety
Target
HRH1, SLC6A2, SLC6A4
Source data
