General
Preferred name
L-NIL
Synonyms
L-NIL hydrochloride ()
L-N6-(1-Iminoethyl)lysine dihydrochloride ()
L-NIL dihydrochloride ()
L-NIL (hydrochloride) ()
P&D ID
PD071200
CAS
159190-45-1
150403-89-7
53774-63-3
Tags
available
drug candidate
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE 29
DESCRIPTION L-NIL is a selective nitric oxide synthase (iNOS) inhibitor that reverses burn-induced activation of glycogen synthase kinase-3?? in rat skeletal muscle and may slow the progression of squamous cell carcinoma lung.
DESCRIPTION L-NIL is a relatively selective inhibitor of iNOS. It prevented ischemic-induced renal microvascular hypoxia via inhibiting iNOS-dependent early changes in renal oxygenation which disrupts the balance between microvascular oxygen supply and Vo(2)(ren). (BOC Sciences Bioactive Compounds)
DESCRIPTION Selective iNOS inhibitor (Tocriscreen Total)
DESCRIPTION L-NIL hydrochloride is a nitric oxide synthase inhibitor with IC50 value of 3.3 μM. (BOC Sciences Bioactive Compounds)
DESCRIPTION L-NIL is a selective nitric oxide synthase (iNOS) inhibitor that reverses burn-induced activation of glycogen synthase kinase-3β in rat skeletal muscle and may slow the progression of squamous cell carcinoma lung. (TargetMol Bioactive Compound Library)
Cell lines
2
Organisms
0
Compound Sets
10
BOC Sciences Bioactive Compounds
l-nil-dihydrochloride-cas-159190-45-1-196646
l-nil-hydrochloride-cas-150403-89-7-362965
Cayman Chemical Bioactives
80310
Drug Repurposing Hub
DrugMAP
DM6Y49D
Mcule NIBR MoA Box Subset
MCULE-5581195825
MedChem Express Bioactive Compound Library
HY-12116
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
TargetMol Bioactive Compound Library
T11805
Tocriscreen Total
External IDs
49
Properties
(calculated by RDKit )
Molecular Weight
187.13
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
4
Rotatable Bonds
6
Ring Count
0
Aromatic Ring Count
0
cLogP
0.16
TPSA
99.2
Fraction CSP3
0.75
Chiral centers
1.0
Largest ring
0.0
QED
0.27
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
NO Synthase
Inos
NOS1, NOS2, NOS3
Member status
member
MOA
Inducible Nitric Oxide Synthase (NOS-2) Inhibitors
nitric oxide synthase inhibitor
Pathway
Immunology/Inflammation
Source data