General
Preferred name
LEUPEPTIN
Synonyms
Leupeptin (hemisulfate) ()
Leupeptin hemisulfate anhydrous ()
Leupeptin Hemisulfate ()
Leupeptin (hemisulfate) ()
P&D ID
PD071192
CAS
103476-89-7
55123-66-5
24365-47-7
Tags
available
covalent binder
drug candidate
Drug indication
Malaria
Drug Status
investigational
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
65
DESCRIPTION
Leupeptin hemisulfate is a protease inhibitor with cell membrane-permeable, reversible, competitive, and oral activities. Leupeptin hemisulfate inhibits the activity of Cathepsin B, Cathepsin H, and Cathepsin L, and blocks fusion of amphipathic lysosomes. Leupeptin hemisulfate also has anti-inflammatory activity.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
9
Cayman Chemical Bioactives
CovBinderInPDB
CZ-OPENSCREEN Bioactive Library
DrugBank
DrugMAP
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Other bioactive compounds
TargetMol Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
52
Molecular Weight
426.3
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
6
Rotatable Bonds
14
Ring Count
0
Aromatic Ring Count
0
cLogP
2.54
TPSA
176.74
Fraction CSP3
0.75
Chiral centers
3.0
Largest ring
0.0
QED
0.11
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Cathepsin
Cysteine Protease
Serine Protease
Ser/Thr Protease
Virus Protease
MOA
Cysteine Protease inhibitor
Serine Protease inhibitor
Pathway
Anti-infection
Metabolic Enzyme/Protease
Proteases/Proteasome
Source data
