General
Preferred name
(+)-PD 128907 hydrochloride
Synonyms
(±)-PD 128,907 hydrochloride ()
S(+)-PD 128,907 hydrochloride ()
(±)-PD 128907 hydrochloride ()
PD128907 HCl ()
(+)-PD 128907 (hydrochloride) ()
P&D ID
PD071170
CAS
300576-59-4
123594-64-9
123671-92-1
112960-16-4
Tags
available
natural product
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Selective GABAB antagonist; brain penetrant
(Tocris Bioactive Compound Library)
DESCRIPTION
Selective D3 dopamine receptor agonist
(LOPAC library)
DESCRIPTION
D3 agonist (D3 ≥ D2 > D4)
(Tocriscreen Total)
DESCRIPTION
PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
10
BOC Sciences Bioactive Compounds
Cayman Chemical Bioactives
Drug Repurposing Hub
LOPAC library
MedChem Express Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Total
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
24
Properties
(calculated by RDKit )
Molecular Weight
249.14
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
1
Rotatable Bonds
2
Ring Count
3
Aromatic Ring Count
1
cLogP
1.94
TPSA
41.93
Fraction CSP3
0.57
Chiral centers
2.0
Largest ring
6.0
QED
0.87
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Selectivity
D3
Pathway
GPCR/G protein
Neuroscience
Neuronal Signaling
Target
dopamine
DRD2, DRD3
D3 agonist
Dopamine Receptor
Primary Target
D3 Receptors
MOA
Agonist
Dopamine Receptor agonist
Source data