General
Preferred name
TAN-67
Synonyms
SB 205607 dihydrobromide ()
TAN-67 (dihydrobromide) ()
SB-213698 ()
SB-205607 (dihydrobromide) ()
P&D ID
PD071062
CAS
1217628-73-3
148545-09-9
Tags
drug candidate
natural product
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
TAN-67 is a potent and selective δ-opioid receptor agonist . It is also an agonist of the orphan GPCR MRGPRX2 .
(GtoPdb)
DESCRIPTION
Selective D1-like agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
SB 205607 dihydrobromide is the first described non-peptide δ1 opioid receptor agonist with high affinity and selectivity for the δ1 subtype (Ki = 1.12, 2320 and 1790 nM at δ1, μ and κ receptors, respectively).
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
6
BOC Sciences Bioactive Compounds
DrugMAP
Guide to Pharmacology
MedChem Express Bioactive Compound Library
NIH Clinical Collections (NCC)
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
26
Molecular Weight
344.19
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
1
Rotatable Bonds
1
Ring Count
5
Aromatic Ring Count
3
cLogP
3.93
TPSA
36.36
Fraction CSP3
0.35
Chiral centers
2.0
Largest ring
6.0
QED
0.73
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
? Opioid Receptors
MOA
Agonist
Pathway
GPCR/G protein
Neuronal Signaling
Target
Opioid Receptor
Source data
