General
Preferred name
A 77636
Synonyms
A-77636 hydrochloride ()
A 77636 hydrochloride ()
A-77636 ()
A-77636 (hydrochloride) ()
A77636 ()
P&D ID
PD070973
CAS
145307-34-2
778546-51-3
Tags
drug candidate
natural product
available
Drug indication
Parkinson disease
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Selective D1 receptor full agonist (GtoPdb)
DESCRIPTION Potent, orally active D1 dopamine receptor agonist (LOPAC library)
DESCRIPTION Potent, selective D1-like agonist. Orally active (Tocriscreen Total)
DESCRIPTION A 77636 hydrochloride is a potent and selective dopamine D1-like receptor agonist (pEC50 = 8.97 and < 5 for D1-like and D2-like receptors, respectively). A 77636 exhibits anti-Parkinsonian activity following oral administration in vivo. (BOC Sciences Bioactive Compounds)
DESCRIPTION Potent and selective A1 agonist (Tocris Bioactive Compound Library)
Cell lines
1
Organisms
2
Compound Sets
15
BOC Sciences Bioactive Compounds
a-77636-hydrochloride-cas-145307-34-2-item-221901
Cayman Chemical Bioactives
24316
Concise Guide to Pharmacology 2019/20
9637
Concise Guide to Pharmacology 2021/22
9637
Concise Guide to Pharmacology 2023/24
9637
Drug Repurposing Hub
DrugMAP
DM0NY6K
EUbOPEN Chemogenomics Library
Guide to Pharmacology
9637
LOPAC library
MedChem Express Bioactive Compound Library
HY-103416
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Tocris Bioactive Compound Library
1701
Tocriscreen Total
External IDs
31
Properties
(calculated by RDKit )
Molecular Weight
329.2
Hydrogen Bond Acceptors
4
Hydrogen Bond Donors
3
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
1
cLogP
3.26
TPSA
75.71
Fraction CSP3
0.7
Chiral centers
2.0
Largest ring
6.0
QED
0.73
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
D1
Primary Target
D1 and D5 Receptors
MOA
Agonist
DRD5 agonist
D1 agonist
Dopamine Receptor agonist
Member status
member
Target
CALY
Dopamine Receptor
Pathway
GPCR/G protein
Neuronal Signaling
Source data