General
Preferred name
EHNA
Synonyms
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride ()
EHNA hydrochloride ()
(2R,3S)-3-(6-Amino-purin-9-yl)-nonan-2-ol ()
EHNA (hydrochloride) ()
P&D ID
PD070886
CAS
58337-38-5
51350-19-7
79813-68-6
79763-32-9
Tags
available
drug candidate
Drug indication
Discovery agent
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
EHNA hydrochloride is a potent and selective dual inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2)(IC50=4 ¦ÌM) and adenosine deaminase (ADA). EHNA hydrochloride exerts a concentration inhibition of the cGMP-stimulated PDE II (cGs-PDE)(IC50:0.8 ¦ÌM (human), 2 ¦ÌM (porcine myocardium)), but has smaller inhibitory effect on the unstimulated PDE2 activity. EHNA hydrochloride play roles in mediating diverse pharmacological responses, including antiviral, antitumour and antiarrhythmic effects[1][2].
PRICE
85
DESCRIPTION
EHNA hydrochloride is a selective inhibitor of cyclic nucleotide phosphodiesterase 2 (PDE2) and adenosine deaminase (ADA) with anticancer activity, increasing intracellular adenosine concentration in a treatment time-dependent manner. EHNA hydrochloride inhibits PHA and NaI04 mitogenesis.
DESCRIPTION
Glycoprotein IIb/IIIa (integrin alphaIIbbeta3) receptor antagonist. Antithrombotic
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent adenosine deaminase inhibitor
(LOPAC library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
13
Cayman Chemical Bioactives
Concise Guide to Pharmacology 2017/18
Concise Guide to Pharmacology 2019/20
Concise Guide to Pharmacology 2021/22
Concise Guide to Pharmacology 2023/24
DrugMAP
Guide to Pharmacology
LOPAC library
LSP-MoA library (Laboratory of Systems Pharmacology)
MedChem Express Bioactive Compound Library
Other bioactive compounds
Tocris Bioactive Compound Library
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
38
Molecular Weight
277.19
Hydrogen Bond Acceptors
6
Hydrogen Bond Donors
2
Rotatable Bonds
7
Ring Count
2
Aromatic Ring Count
2
cLogP
2.3
TPSA
89.85
Fraction CSP3
0.64
Chiral centers
2.0
Largest ring
6.0
QED
0.76
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Selectivity
Adenosine deaminase
Primary Target
Deaminases
MOA
Inhibitor
Pathway
Anti-infection
Metabolic Enzyme/Protease
Target
Adenosine Deaminase
Influenza Virus
Phosphodiesterase (PDE)
Source data
