General
Preferred name
IONOMYCIN
Synonyms
SQ23377 ()
Ionomycin (calcium) ()
SQ23377 (calcium) ()
IONOMYCIN CALCIUM ()
Ionomycin (calcium salt) ()
P&D ID
PD070874
CAS
56092-82-1
56092-81-0
Tags
available
natural product
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Ionomycin calcium (SQ23377 calcium) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin calcium (SQ23377 calcium) also induces the activation of protein kinase C (PKC)[1][2][3].
PRICE 22
DESCRIPTION Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, demonstrating high specificity for divalent cations (Ca>Mg>Sr=Ba).
DESCRIPTION Ionomycin is a polyether, ionophore antibacterial originally isolated from the fermentation broth of Streptomyces conglobatus . It is used in research laboratories to study the effects of increasing intracellular Ca++ concentrations. (GtoPdb)
PRICE 55
DESCRIPTION Ionomycin is an calcium ionophore and an antibiotic that binds calcium ions (Ca2+). It is produced by the bacterium Streptomyces conglobatus.It is used in research to raise the intracellular calcium level (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. Ionomycin promotes apoptosis and induces the activation of protein kinase C (PKC).
Compound Sets
4
Cayman Chemical Bioactives
11932
CZ-OPENSCREEN Bioactive Library
Guide to Pharmacology
13591
MedChem Express Bioactive Compound Library
HY-13434A
External IDs
36
Properties
(calculated by RDKit )
Molecular Weight
708.52
Hydrogen Bond Acceptors
8
Hydrogen Bond Donors
5
Rotatable Bonds
22
Ring Count
2
Aromatic Ring Count
0
cLogP
7.8
TPSA
153.75
Fraction CSP3
0.85
Chiral centers
14.0
Largest ring
5.0
QED
0.04
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Calcium Channel
Apoptosis
PKC
antibiotic
Bacterial
Pathway
Membrane Transporter/Ion Channel
Neuronal Signaling
TGF-beta/Smad
Epigenetics
Anti-infection
Source data