General
Preferred name
BMS-182874
Synonyms
BMS 182874 hydrochloride ()
CHEMBL267458 ()
BMS182874 ()
BMS 182874 ()
P&D ID
PD070785
CAS
1215703-04-0
153042-42-3
Tags
available
probe
drug candidate
Drug indication
Hypertension
Probe info
Probe type
P&D approved
calculated probe
Probe selectivity
protein-selective
Probe sources
High-quality chemical probes
Tool Compound Set
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Probe control not defined
Orthogonal probes
3
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
191
DESCRIPTION
BMS 182874 is an orallyactive, highly selective endothelin receptor (ETA receptor) antagonist, with IC50 value of 0.150 ¦ÌM, Ki of 0.055 ¦ÌM. BMS 182874 reduces the arterial pressure of Deoxycorticosterone acetate (HY-B1472) induced hypertension model in rats, and can be used for cardiovascular disease research[1].
PRICE
120
DESCRIPTION
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 ??M for ETA and a Ki value of 0.055 ??M for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease.
DESCRIPTION
D1 agonist
(Tocris Bioactive Compound Library)
DESCRIPTION
Highly selective, orally active non-peptide ETA antagonist
(Tocriscreen Plus)
DESCRIPTION
Highly selective, orally active non-peptide ETA antagonist
(Tocriscreen Total)
DESCRIPTION
BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
(TargetMol Bioactive Compound Library)
DESCRIPTION
BMS 182874 is an endothelin receptor antagonist used as an antihypertensive agent.
(BOC Sciences Bioactive Compounds)
DESCRIPTION
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease.
(TargetMol Bioactive Compound Library)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
13
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
DrugMAP
DrugMatrix
High-quality chemical probes
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
ReFrame library
Tocris Bioactive Compound Library
Tocriscreen Plus
Tocriscreen Total
Tool Compound Set
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
29
Molecular Weight
345.11
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
4
Ring Count
3
Aromatic Ring Count
3
cLogP
3.31
TPSA
75.44
Fraction CSP3
0.24
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endothelin Receptor
Endothelin receptor ET-A
ET-A
EDNRA
Target Type
7-TM Receptors
Primary Target
ETA Receptors
MOA
Antagonist
EDNRA antagonist
Endothelin ETA Receptor Antagonists
Endothelin Receptor antagonist
Member status
member
Pathway
GPCR/G protein
Source data
