General
Preferred name
Leu-Enkephalin
Synonyms
Leucine enkephalin ()
Leucyl-enkephalin ()
Leucine-enkephalin ()
[Leu5]-Enkephalin ()
[Leu5]-Enkephalin TFA(58822-25-6(free bas)) ()
[Leu5]-Enkephalin acetate(58822-25-6 free base) ()
ENKEPHALIN ()
Leu-Enkephalin (trifluoroacetate salt) ()
P&D ID
PD070737
CAS
59141-40-1
58822-25-6
73563-78-7
Tags
available
drug candidate
biased GPCR ligand
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION [Leu5]-Enkephalin (Leu-enkephalin) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively) (TargetMol Bioactive Compound Library)
DESCRIPTION [Leu5]-Enkephalin TFA(58822-25-6(free bas)) (Leucyl-enkephalin) is the most potent δ-receptor ago (TargetMol Bioactive Compound Library)
DESCRIPTION [Leu5]-Enkephalin acetate(58822-25-6 free base) is an endogenous neuropeptide involved in nociception and an agonist of δ-opioid and μ-opioid receptors (Kis = 4.0 and 3.4 nM, respectively) (TargetMol Bioactive Compound Library)
Cell lines
0
Organisms
3
Compound Sets
8
BiasDB
Leu-enk
Cayman Chemical Bioactives
23283
CZ-OPENSCREEN Bioactive Library
DrugMAP
DMT2CZK
EU-OPENSCREEN Bioactive Compound Library
EOS100987
EUbOPEN Chemogenomics Library
EUB0000536
MedChem Express Bioactive Compound Library
HY-P0288
TargetMol Bioactive Compound Library
T7173
T7665
T7173L
External IDs
57
Properties
(calculated by RDKit )
Molecular Weight
555.27
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
7
Rotatable Bonds
15
Ring Count
2
Aromatic Ring Count
2
cLogP
-0.16
TPSA
199.95
Fraction CSP3
0.39
Chiral centers
3.0
Largest ring
6.0
QED
0.16
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
Endogenous Metabolite
Opioid Receptor
Human Endogenous Metabolite
δ-opioid receptor
μ-opioid receptor
Pathway
Endocrinology/Hormones
GPCR/G protein
Metabolism
Neuroscience
Metabolic Enzyme/Protease
Neuronal Signaling
Recommended Cell Concentration
1 uM
Source data