General
Preferred name
PNU-22394
Synonyms
PNU 22394 hydrochloride ()
PNU-22394 (hydrochloride) ()
PNU 22394 (hydrochloride) ()
P&D ID
PD070687
CAS
15923-42-9
15923-78-1
Tags
available
drug candidate
Drug indication
Discovery agent
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION PNU-22394 hydrochloride is an agonist for 5-HT, with Ki of 6.1 and 10 nM, for 5-HT2C and 5-HT2A, respectively[1].
PRICE 94
DESCRIPTION 5-HT2C agonist and 5-HT2A/2B partial agonist (Tocriscreen Total)
DESCRIPTION PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist (TargetMol Bioactive Compound Library)
Compound Sets
8
Axon Medchem Screening Library
1247
Cayman Chemical Bioactives
43564
Drug Repurposing Hub
DrugMAP
DMHTPSF
MedChem Express Bioactive Compound Library
HY-103145
ReFrame library
TargetMol Bioactive Compound Library
T23168
Tocriscreen Total
External IDs
38
Properties
(calculated by RDKit )
Molecular Weight
200.13
Hydrogen Bond Acceptors
2
Hydrogen Bond Donors
1
Rotatable Bonds
0
Ring Count
3
Aromatic Ring Count
2
cLogP
1.87
TPSA
16.96
Fraction CSP3
0.38
Chiral centers
0.0
Largest ring
7.0
QED
0.69
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
5-HT2A
5-HT2B
5-HT2C
HTR2A, HTR2B, HTR2C, MAOA, MAOB
5-HT2C agonist
5-HT Receptor
MOA
serotonin receptor agonist
Pathway
GPCR/G protein
Neuronal Signaling
Neuroscience
Source data