General
Preferred name
U 90042
Synonyms
U-90042 ()
P&D ID
PD070672
CAS
134516-99-7
Tags
available
drug candidate
Drug indication
Anxiety disorder
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
U 90042 is a GABAA receptor ligand binding to three receptor subtypes: α1β2γ2, α3β2γ2 and α6β2γ2 (Ki = 7.8, 9.5 and 11.0 nM, respectively). U 90042 potentiates GABA-induced chloride currents in α6β2γ2 receptors. U 90042 is used as a sedative/hypnotic.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
3
BOC Sciences Bioactive Compounds
DrugMAP
ReFrame library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
9
Molecular Weight
352.08
Hydrogen Bond Acceptors
7
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
6
Aromatic Ring Count
3
cLogP
3.03
TPSA
72.34
Fraction CSP3
0.29
Chiral centers
0.0
Largest ring
6.0
QED
0.71
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Source data
