General
Preferred name
U-89843A
Synonyms
U 89843A ()
P&D ID
PD070670
CAS
157013-85-9
157013-32-6
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
PRICE
97
DESCRIPTION
U 89843A is a positive allosteric modulator of gamma-aminobutyric acid (GABA)A receptors.
(TargetMol Bioactive Compound Library)
DESCRIPTION
alpha4beta2 nAChR ligand; may act as an agonist or a desensitizer
(Tocris Bioactive Compound Library)
DESCRIPTION
U 89843A is a positive allosteric modulator of GABAA receptors. U 89843A potentiates GABA-induced Cl- currents in the α1β2γ2, α3β2γ2 and α6β2γ2 GABAA receptors. U 89843A exhibits sedative activity following i.v. administration without losing "righting reflex" and also displays antioxidant activity.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
2
Compound Sets
5
BOC Sciences Bioactive Compounds
Drug Repurposing Hub
ReFrame library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
19
Molecular Weight
285.2
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
0
Rotatable Bonds
2
Ring Count
4
Aromatic Ring Count
2
cLogP
2.48
TPSA
37.19
Fraction CSP3
0.62
Chiral centers
0.0
Largest ring
6.0
QED
0.85
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target
GABAA
GABBR1
Primary Target
GABAA Receptors
MOA
Modulator
benzodiazepine receptor agonist
Pathway
Membrane Transporter/Ion Channel
Neuroscience
Source data
