General
Preferred name
L-365260
Synonyms
L-365,260 ()
2016-06-07: L 365260 ()
LY-365260 ()
P&D ID
PD070653
CAS
118101-09-0
Tags
drug candidate
natural product
probe
available
Drug indication
Anxiety disorder
Probe info
Probe selectivity
protein-selective
Probe type
P&D approved
calculated probe
experimental probe
Probe targets
[[ compound.targets[t].gene_name ]]
Probe control
Orthogonal probes
1
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA
Antagonist
(Chemical Probes.org)
DESCRIPTION
Selective CCR1 antagonist
(Tocris Bioactive Compound Library)
DESCRIPTION
L-365,260 is a nonpeptide cholecystokinin receptor 2 (CCK2/CCKB) antagonist. It selectively binds to gastrin and CCK2 sites to reduce basal acid secretion, and prevent gastrointestinal damage in models of peptic ulcer disease.
(BOC Sciences Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
1
Organisms
0
Compound Sets
11
BOC Sciences Bioactive Compounds
Chemical Probes.org
Drug Repurposing Hub
DrugMAP
EUbOPEN Chemogenomics Library
High-quality chemical probes
MedChem Express Bioactive Compound Library
Novartis Chemogenetic Library (NIBR MoA Box)
Probe Miner (suitable probes)
ReFrame library
Tocris Bioactive Compound Library
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
18
Molecular Weight
398.17
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
2
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
3.96
TPSA
73.8
Fraction CSP3
0.12
Chiral centers
1.0
Largest ring
7.0
QED
0.7
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
CCK2 Receptors
MOA
Antagonist
CCK2 (CCKB/Gastrin) Antagonists
CCK receptor antagonist
Member status
member
Target
CCKAR, CCKBR, KCNQ1
Cholecystokinin Receptor
CCKBR
Pathway
GPCR/G protein
Neuronal Signaling
Target class
GPCR
Control
CANSAR236284
Source data
