General
Preferred name
PF-670462
Synonyms
PF 670462 ()
PF670462 ()
PF-670462 (dihydrochloride) ()
PF-670462 (hydrochloride) ()
PF-00670462 ()
P&D ID
PD070629
CAS
950912-80-8
950980-98-0
Tags
available
drug candidate
Drug indication
Chronic lymphocytic leukaemia
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase (CK1¦Å and CK1¦Ä), with IC50s of 7.7 nM and 14 nM, respectively.
PRICE
93
DESCRIPTION
PF-670462 is a potent (IC50 = 7.7 ?? 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1?? in isolated enzyme preparations.
DESCRIPTION
We show the parent molecule of PF-670462 here. It is described in the original literature report as the dihydrochloride salt (PubChem CID 51049607) . PF-670462 is a selective inhibitor of casein kinase I epsilon (CKIε).
(GtoPdb)
DESCRIPTION
IKKbeta inhibitor; attenuates NF-kappaB-induced gene expression
(Tocris Bioactive Compound Library)
DESCRIPTION
Potent and selective CK1epsilon and CK1delta inhibitor
(Tocriscreen Plus)
DESCRIPTION
PF-670462 is a potent (IC50 = 7.7 ± 2.2 nM) and selective (>30-fold with respect to 42 additional kinases) inhibitor of CK1ε in isolated enzyme preparations.
(TargetMol Bioactive Compound Library)
DESCRIPTION
PF-00670462 is a potent inhibitor of the CK1 isoforms CK1ε and CK1δ. It also blocks the locomotor response to amphetamines in mice.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Cell lines
0
Organisms
1
Compound Sets
15
AdooQ Bioactive Compound Library
Cayman Chemical Bioactives
CZ-OPENSCREEN Bioactive Library
Drug Repurposing Hub
DrugMAP
Enamine Bioactive Compounds
EU-OPENSCREEN Bioactive Compound Library
EUbOPEN Chemogenomics Library
Guide to Pharmacology
MedChem Express Bioactive Compound Library
Selleckchem Bioactive Compound Library
TargetMol Bioactive Compound Library
Tocris Bioactive Compound Library
Tocriscreen Plus
ZINC Tool Compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
33
Molecular Weight
337.17
Hydrogen Bond Acceptors
5
Hydrogen Bond Donors
1
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
3
cLogP
4.23
TPSA
69.62
Fraction CSP3
0.32
Chiral centers
0.0
Largest ring
6.0
QED
0.78
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Target Type
Enzymes
Target
Casein kinase
CK1ε
CSNK1D, CSNK1E
Primary Target
Casein Kinase 1
MOA
Inhibitor
Casein Kinase inhibitor
Pathway
Cell Cycle/DNA Damage
Stem Cell/Wnt
Metabolism
Stem Cells
Recommended Cell Concentration
None
Source data
