General
Preferred name
FK506
Synonyms
Fujimycin ()
FR900506 ()
TACROLIMUS ()
Prograf ()
tacrolimus / FK-506 ()
Tacrolimus ()
P&D ID
PD070373
CAS
104987-11-3
109581-93-3
Tags
available
Probe control
Probe control not defined
Orthogonal probes
0
No orthogonal probes found
Similar probes
0
No structurally similar probes found
Structure
P&D probe-likeness score
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION
Tacrolimus is a calcineurin inhibitor used to prevent organ transplant rejection and to treat moderate to severe atopic dermatitis.
(Enamine Bioactive Compounds)
[[ p.pathway_name ]]
[[ compound.targets[tid].gene_name ]]
Compound Sets
4
Enamine Bioactive Compounds
Enamine BioReference Compounds
Natural product-based probes and drugs
Other bioactive compounds
[[ a.name ]]
[[ ligand_id ]]
free of charge
External IDs
15
Molecular Weight
803.48
Hydrogen Bond Acceptors
12
Hydrogen Bond Donors
3
Rotatable Bonds
7
Ring Count
4
Aromatic Ring Count
0
cLogP
4.64
TPSA
178.36
Fraction CSP3
0.77
Chiral centers
14.0
Largest ring
21.0
QED
0.18
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
MOA
mTOR
Pathway
PI3K/Akt/mTOR signaling
Target
FKBP-12
Biosynthetic Origin
Polyketide, Peptide (NRPS)
Therapeutic Indication
Immunosuppressant
Therapeutic Class
Immunomodulatory
Source data
