General
Preferred name
phosphocreatine
Synonyms
Phosphocreatine disodium salt hydrate ()
Phosphocreatine disodium salt ()
Disodium phosphocreatine ()
Phosphocreatine (disodium) ()
FOSFOCREATINE ()
Disodium creatine phosphate ()
Creatine phosphate disodium salt ()
Phosphagen ()
Phosphocreatine ()
Creatine-p ()
Creatine Phosphate ()
Creatine Phosphate (sodium salt hydrate) ()
P&D ID
PD070224
CAS
19333-65-4
922-32-7
18838-38-5
67-07-2
Tags
natural product
drug
available
Drug Status
nutraceutical
investigational
approved
Max Phase
Phase 3
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
MOA Adenosine triphosphate (ATP) is the primary source of chemical energy that body muscles use to perform contractions. During such contraction processes, ATP molecules are depleted as they undergo hydrolysis reactions and become adenosine diphosphate (ADP). To maintain homeostasis in muscle activity, the ATP supply of muscles must be regenerated regularly.; ; Phosphocreatine occurs naturally within the body and is capable of regenerating ATP by transferring a high-energy phosphate from itself to ADP, resulting in the formation of ATP and creatine. This kind of regeneration of ATP with phosphocreatine typically occurs within seconds of intense muscular or neuronal effort, acting as a quickly accessible reserve of high-energy phosphates for the recycling of ATP in body muscle tissues. ATP recycling from phosphocreatine is in fact known as the quickest form of ATP regeneration.
INDICATION Phosphocreatine is a naturally occuring substance that is found predominantly in the skeletal muscles of vertebrates. Its primary utility within the body is to serve in the maintanence and recycling of adenosine triphosphate (ATP) for muscular activity like contractions.; ; Given this utility of phosphocreatine to recycle ATP, the most plausible therapeutic potentials for its use involve conditions caused by energy shortage or by increased energy requirements - such as in ischemic stroke and other cerebrovascular diseases. It is important to note however that relatively little clinical research has been done to significantly further the evidence for any such indications, although it is administered intravenously for cardiovascular conditions in some countries.; ; Additionally, because phosphocreatine is not regulated as a controlled substance it is taken as a supplement by some professional athletes as a means to perhaps increase short bursts of muscle strength or energy for professional athletics.
ROE Phosphocreatine is eliminated renally. ; ; The end result of creatine degredation is the product creatinine, which enters the bloodstream from its storage sites in body muscle. When creatinine enters the renal parenchyma it is filtered in the renal glomerulus to be excreted in the urine.
PHARMACODYNAMICS Creatine is a naturally occurring chemical within the body and is primarily stored in skeletal muscle in both free and phosphorylated forms. Phosphocreatine is the name given to the phosphorylated form of creatine. Additionally, phosphocreatine can also be found in other areas of the body like the kidneys, liver, and brain. In fact, most *in vivo* synthesis of creatine occurs in the liver where amidine groups from arginine are transfered to glycine with the help of the glycine transaminidase enzyme to form guanidinoacetic acid. This acid is then methylated with the methyl group of S-adenosylmethionine via guanidinoacetate methyltransferase to generate creatine. The synthesized creatine is transported to storage sites in skeletal muscle via the bloodstream.; ; The phosphorylation of creatine is reversible in both a forwards and backwards reaction. That is, while phosphocreatine is capable of anaerobically donating a phosphate group to adenosine diphosphate (ADP) to regenerate ATP, at the same time excess ATP can be dephosphorylated during periods of low muscle activity to convert creatine to phosphocreatine. This dual activity in synthesizing phosphocreatine from excess levels of ATP during rest and use of phosphocreatine to regenerate ATP during high activity demonstrates the crucial utility of phosphocreatine in acting as an energy buffer in body mucle cells. ; ; Phosphocreatine's fast regeneration of ATP is considered a coupled reaction - in essence, the energy released from transferring a donating a phosphate group from phosphocreatine is used to regenerate ATP. Phosphocreatine consequently plays an essential role in body tissues that have high, fluctuating energy requirments like muscle and brain tissues.
DESCRIPTION High affinity dopamine uptake inhibitor (Tocris Bioactive Compound Library)
Compound Sets
10
Cayman Chemical Bioactives
35598
37803
ChEMBL Drugs
CHEMBL1204644
DrugBank
DB13191
DrugCentral
3464
DrugCentral Approved Drugs
3464
MedChem Express Bioactive Compound Library
HY-D0885B
Other bioactive compounds
Selleckchem Bioactive Compound Library
creatine-phosphate-disodium-salt
TargetMol Bioactive Compound Library
T4888
Tocris Bioactive Compound Library
4325
External IDs
85
Properties
(calculated by RDKit )
Molecular Weight
211.04
Hydrogen Bond Acceptors
3
Hydrogen Bond Donors
5
Rotatable Bonds
3
Ring Count
0
Aromatic Ring Count
0
cLogP
-1.38
TPSA
133.95
Fraction CSP3
0.5
Chiral centers
0.0
Largest ring
0.0
QED
0.22
Structural alerts
0
No structural alerts detected
Related compounds
Custom attributes
(extracted from source data)
Primary Target
Miscellaneous Compounds
Pathway
Metabolic Enzyme/Protease
Target
Endogenous Metabolite
Source data